Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol.
نویسندگان
چکیده
A lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
منابع مشابه
Synthesis of 188 Re-labelled long chain alkyl diaminedithiol for therapy of liver cancer.
Radioisotope-labelled lipiodol has been used in the therapy of liver cancer. Recently a lipiodol solution of 188Re-labelled diaminedithiol (DD) has been reported to show a high uptake in the liver cancer. We synthesized long-chain alkyl DD derivatives to improve their uptake and retention in tissue. As the length of the alkyl chain increased, tissue uptake and retention also increased due to hy...
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ورودعنوان ژورنال:
- Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
دوره 65 1 شماره
صفحات -
تاریخ انتشار 2007